洪亮 特别研究员
研究机构: 交叉科学研究所
研究领域: 生物物理
办公地点: 理科楼5号楼336
办公电话: 86-21-54742996
研究方向: 1、蛋白质玻璃化转变及蛋白质类产品低温保存技术 2、蛋白质的非平衡态动力学 3、小角散射研究蛋白质以及复杂体系的结构 4、蛋白质表面水分子的分数阶运动


2006-2010  美国阿克伦大学高分子科学系 (导师: Alexei P. Sokolov)

2004-2006  香港中文大学物理系 (导师:郝少康)

2000-2004   中国科学技术大学物理系

2015-至今   AG视讯厅物理天文系&自然科学研究院 特别研究员,博导

2010-2014   美国橡树岭国家实验室 博士后 (师从Jeremy C. Smith)



  • X. Hu, L. Hong, M. Smith, T. Neusius, X. Cheng, and J.C. Smith “The Dynamics of Single Protein Molecules is Nonequilibrium and Self-Similar over Thirteen Decades in Time.”Nature Physics 12, 171–174 (2016)
  • D. Vural, X. Hu, B. Lindner, N. Jain, Y. Miao, X. Cheng, Z. Liu, L. Hong, and J. C. Smith, “Quasielastic neutron scattering in biology: Theory and applications,” Biochim. Biophys. Acta, 2016.
  • L. Hong, N. Jain, X. Cheng, A. Bernal, M. Tyagi, and J. C. Smith, “Determination of functional collective motions in a protein at atomic resolution using coherent neutron scattering,”Sci. Adv., Vol. 2, no. 10, e1600886, pp. 1–8, 14 Oct 2016.
  • G.K. Dhindsa, D. Bhowmik, M. Goswami, H.M. O'Neill, E. Mamontov, B.G. Sumpter, L. Hong, P. Ganesh, and X.-Q. Chu*, “Enhanced Dynamics of Hydrated tRNA on Nanodiamond Surfaces: A Combined Neutron Scattering and MD Simulation Study”, J. Phys. Chem. B, DOI: 10.1021/acs.jpcb.6b07511 (2016).
  • C. Dalle-Ferrier, A. Kisliuk, L. Hong, G. C. Jr., G. Carini, G. D’Angelo, C. Alba-Simionesco, V. N. Novikov, and A. P. Sokolov, “Why many polymers are so fragile: A new perspective,” J. Chem. Phys., vol. 145, no. 15, p. 154901, 2016.


AG视讯厅:before coming to INS



  • D. Vural, L. Hong, J. C. Smith, and H. R. Glyde, “Motional displacements in proteins: The origin of wave-vector-dependent values,” Phys. Rev. E, vol. 91, no. 5, pp. 1–11, 2015.



  • L. Hong, M. Sharp, S. Poblete, R. Bhiel, X. Cheng, D. Richter and J. C. Smith “Detailed structure and dynamics of a compact state of a multidomain protein, the mercuric ion reductase, in aqueous solution”, Biophys. J.,107, 393,(2014).
  • L. Hong, L. Petridis and J. C. Smith “Biomolecular Structure and Dynamics with Neutrons: The View from Simulation.”, Isr. J.Chem. 54, 1264 (2014).
  • L. Hong, N. Smolin and J. C. Smith “De Gennes Narrowing Describes the Relative Motion of Protein Domains”, Phys. Rev. Lett., 112, 158102 (2014).



  • Y. Miao, L. Hong, Z. Yi and J. C. Smith “Zaccai Resilience and Site-specific Hydration in a Globular Protein”, The European Physical Journal E, 36, 9885 (2013).
  • L. Hong, D.C. Glass, J.D. Nickels, Z. Yi, T. Madhusudan, H. O’Neill, A. P. Sokolov and J.C. Smith “Elastic and conformational softness of a globular protein”, Phys. Rev. Lett., 110, 028104 (2013).



  • Y.L. Miao, Z. Yi, D.C. Glass, L. Hong, M. Tyagi, J. Baudry, N. Jain and J.C. Smith. “Temperature-Dependent Dynamical Transitions of Different Classes of Amino Acid Residue in a Globular Protein”, J. Am. Chem. Soc. 134, 19576 (2012).
  • J.D. Nickels, H. O’Neill, L. Hong, M. Tyagi, G. Ehlers, K. Weiss, Q. Zhang, Z. Yi, E. Mamontov, J.C. Smith and A.P. Sokolov. “Dynamics of Protein and its Hydration Water: Neutron Scattering Studies on Fully Deuterated GFP”,Biophys. J. 103, 1566 (2012).
  • L. Hong, X. Cheng, D.C. Glass, and J.C. Smith. “Surface hydration amplifies single-well protein atom diffusion propagating into the macromolecular core”, Phys. Rev. Lett., 108, 238102 (2012).



  • L. Hong, N. Smolin, B. Lindner, A.P. Sokolov, and J.C. Smith. “Three classes of motion in the dynamic neutron scattering susceptibility of a globular protein”, Phys. Rev. Lett., 107, 148102 (2011).
  • L. Hong, V.N. Novikov, and A.P. Sokolov. “Dynamic heterogeneities, boson peak, and activation volume in glass-forming liquids”, Phys. Rev. E, 83, 061508 (2011).
  • L. Hong, V.N. Novikov, and A.P. Sokolov. “Is there any connection between fragility of glass forming systems and dynamic heterogeneity /cooperativity?”, J. Non-Cryst. Solids, 357, 351 (2011).


  • L. Hong, B. Begen, A. Kisliuk, V.N. Novikov, and A.P. Sokolov. “Influence of pressure on fast picosecond relaxation in glass-forming materials”, Phys. Rev. B, 81, 104207 (2010).



  • L. Hong, P.D. Gujrati, V.N. Novikov, and A.P. Sokolov. “Molecular cooperativity in the dynamics of glass-forming systems: A new insight”, J. Chem. Phys., 131, 194511 (2009).
  • L. Hong, B. Begen, A. Kisliuk, S. Pawlus, M. Paluch, and A.P. Sokolov. “Influence of pressure on quasielastic scattering in glasses: Relationship to the boson peak”, Phys. Rev. Lett., 102, 145502 (2009).



  • L. Hong, B. Begen, A. Kisliuk, C. Alba-Simionesco, V.N. Novikov, and A.P Sokolov. “Pressure and density dependence of the boson peak in polymers”, Phys. Rev. B, 78,134201 (2008).
  • G. Carini Jr, G. Carini, G. D’Angelo, G. Tripodo, A. Bartolotta, G. Salvato, and L. Hong. “Low temperature Specific heat of heterocyclic polymer networks: Effect of network density”, Phil. Mag., 88, 3999 (2008).
  • S. Pawlus, K. Kunal, L. Hong, and A.P. Sokolov. “Influence of molecular weight on dynamic crossover temperature in linear polymers”, Polymer, 49, 2918 (2008).



  • L. Hong, Z. Liu, X.T. Zhang, and S.K. Hark. “Self-catalytic growth of single-phase AlGaN alloy nanowires by chemical vapor deposition”, Appl. Phys. Lett., 89, 193105 (2006).
  • L. Hong, Z.R. Wang, and S.K. Hark. “Relationship of the SERRS of CV and the concentration of Ag colloids”, Chin. J.Light Scattering, 18, 21 (2006).